Pennapa Chonpathompikunlert
Thailand Institute of Scientific and Technological Research, Thailand
Title: Astaxanthin and encapsulated astaxanthin from white shrimp shell alleviates cognitive impairment in animal model of Alzheimer’s Disease
Biography
Biography: Pennapa Chonpathompikunlert
Abstract
Astaxanthin is a carotenoid with powerful antioxidant and anti-inflammatory activity. However, the effects of astaxanthin and encapsulated astaxanthin from white shrimp shell (Litopenaeus Vannamei) on Alzheimer’s Disease (AD) has not been elucidated) AD was induced by i.c.v. administration of Amyloidbeta (1-42) peptides in rats. This study aimed to investigate the effect of astaxanthin extract and encapsulated astaxanthin on cognition function.
Astaxanthin significantly reversed the cognitive and memory impairment, assessed by the Morris water maze test, Novel Object Recognition test and Novel Object Location test. Astaxanthin is able to act against oxidative injuries, through various mechanisms, by inhibiting superoxide anion, reduction of malondialdehyde (MDA) and protein oxidation product levels, increasing the levels or stimulating the activity of glutathione peroxidase enzymes in the cortex and hippocampus.
Astaxanthin 10 mg/kg encapsulated using cryogenic incorporated freeze-drying showed the similar effect with astaxanthin commercial 10 mg/kg and better effect with astaxanthin extract 10 mg/kg and vitamin E 100 mg/kg. Our study concludes preventive of astaxanthin, acting on cognitive functions and neurodegeneration caused by Aβ (1-42) peptides infused Wistar rats.