Pierpaolo Croce
Institute for Advanced Biomedical Technologies, Italy
Title: Evidence of neurovascular un-coupling in mild Alzheimer’s disease through multimodal EEGfNIRS and multivariate analysis of resting-state data
Biography
Biography: Pierpaolo Croce
Abstract
Alzheimer’s Disease (AD) is associated with modifications in cerebral blood perfusion and autoregulation. Hence, Neurovascular Coupling (NC) alteration could become a biomarker of the disease. NC might be assessed in clinical settings through multimodal electroencephalography (EEG) and Functional Near-Infrared Spectroscopy (fNIRS).
Multimodal EEG-fNIRS was recorded at rest in an ambulatory setting to assess NC and to evaluate the sensitivity and specificity of the methodology to AD. Global NC was evaluated with a general linear model (GLM) framework by regressing whole-head EEG power envelopes in three frequency bands (theta, alpha and beta) with average fNIRS oxy-and deoxy-hemoglobin concentration changes in the frontal and prefrontal cortices.
NC was lower in AD compared to healthy controls (HC) with significant differences in the linkage of theta and alpha bands with oxy-and deoxy-hemoglobin, respectively (p= 0.028 and p= 0.020). Importantly, standalone EEG and fNIRS metrics did not highlight differences between AD and HC. Furthermore, a multivariate datadriven analysis of NC between the three frequency bands and the two hemoglobin species delivered a crossvalidated classification performance of AD and HC with an Area Under the Curve, AUC= 0.905 (p= 2.17× 10− 5). The findings demonstrate that EEG-fNIRS may indeed represent a powerful ecological tool for clinical evaluation of NC and early identification of AD