Principal Research Scientist
Geisel School of Medicine
Catherine Chang is the co-Principal Investigator of the Chang laboratory at Geisel School of Medicine at Dartmouth, with her husband and long-term collaborator Dr. T.Y. Chang as the PI. They have been working on cholesterol metabolism research for more than four decades. The Changs and their colleagues did ground breaking work by identifying the gene that encodes the cholesterol storage enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1/SOAT1). Subsequently, they performed extensive functional analysis of the enzyme. More recently, they demonstrated ACAT1 as a potential target for treating several human diseases, including Alzheimer’s disease and Niemann-Pick type C disease.
Alzheimer’s disease and Niemann-Pick type C disease, cholesterol storage enzyme.