Geisel School of Medicine
TY Chang shares the same laboratory with his wife and long-term collaborator Dr. Catherine Chang at Geisel School of Medicine at Dartmouth. They have been working on cholesterol metabolism research for more than four decades. The Changs and their colleagues did ground breaking work by identifying the gene that encodes the cholesterol storage enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1/SOAT1). For this work, Dr. T.Y. Chang received a MERIT award from NIH, USA. More recently, the Chang lab at Dartmouth demonstrated ACAT1 as a potential target for treating several human diseases, including Alzheimer’s disease and Niemann-Pick type C disease.
Niemann-Pick type C disease, Alzheimer’s disease, cholesterol homeostasis.