Alzheimer’s Disease & Dementia

Chang is internationally known for his research work in the cholesterol metabolism field. His laboratory did ground breaking work on the key cholesterol storage enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1/SOAT1). He and his colleagues identified the Acat1/Soat1 gene, performed functional analysis of the enzyme, and demonstrated Acat1/Soat1 as a target for treating several human diseases including Alzheimer’s disease. Dr. Changhas served as an editorial board member of several major scientific journals, and as a review panel member for NIH. He received an NIH Merit Award in 1994, and was elected AAAS Fellow in 2011.