Alzheimer’s Disease Pathophysiology and Disease Mechanisms

Alzheimer's disease is a progressive dementia characterised by neuron loss and the presence of two major microscopic neuropathological hallmarks: living thing amyloid plaques and living thing neurofibrillary tangles. Early-onset Alzheimer's disease, a rare family form, is caused by a mutation in one of three genes: (amyloid precursor protein), (presenilin 2), or (presenilin 1). Noncontinuous type occurs most commonly after the age of sixty-five and accounts for many occurrences; it may be caused by a combination of hereditary and environmental factors. Amyloid plaques are mostly composed of the toxin amide amyloid which is broken sequentially from a larger precursor super molecule by two enzymes: -secretase (also known as BACE1) and -secretase.

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