Molecular Genetics and Biology of Dementia

Alzheimer’s disease and Frontotemporal Dementia are two basic common types of neurodegenerative dementias. Considerable progress has been made in our understanding of the genetics and molecular biology of dementia. This progress in genetic research is having a dramatic effect on our understanding of disease pathogenesis, by refining previous ideas and defining new primary disease mechanisms. The study of the molecular genetics and biology of dementia is pivotal in understanding the underlying mechanisms that drive the progression of various forms of dementia, including Alzheimer's disease, frontotemporal dementia, Lewy body dementia, and vascular dementia. This field of research delves into the genetic mutations, molecular pathways, and cellular processes that contribute to the onset and progression of these neurodegenerative disorders.Genetics plays a crucial role in the development of dementia. Several genes have been identified that significantly increase the risk of developing Alzheimer's disease, the most common form of dementia. For instance,

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