Alzheimers Disease & Dementia

Neuroinflammation, Microglial Function & Immune Modulation

Neuroinflammation plays a central role in Alzheimer’s disease, with microglia acting as key regulators of immune responses in the brain. Dysfunctional microglial activation contributes to synaptic loss, amyloid accumulation, and accelerated neurodegeneration. Research is advancing understanding of how cytokine signaling, inflammasome activity, and immune-mediated oxidative stress shape disease progression. Modulating microglial phenotypes shifting them from pro-inflammatory to neuroprotective states offers promising therapeutic potential. Novel drugs, monoclonal antibodies, and small molecules are being developed to regulate immune signaling pathways and restore balanced neuroimmune responses. Neuroinflammation biomarkers are increasingly used to stratify patients and guide personalized therapy decisions. Integrating immune modulation with other therapeutic strategies enhances the potential to slow cognitive decline and protect structural brain integrity.