Vascular Contributions to Cognitive Impairment & Aging

Vascular dysfunction significantly contributes to cognitive impairment, interacting with amyloid and tau pathology to accelerate decline. Reduced cerebral perfusion, microvascular injury, and endothelial dysfunction damage neurons and impair metabolic efficiency. Research explores therapeutic approaches including vascular-targeted drugs, antihypertensives, antithrombotics, and lifestyle interventions that improve cerebrovascular integrity. Identifying early vascular biomarkers supports intervention long before cognitive symptoms emerge.

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