Therapeutic Targets and Mechanisms for Treatment

Alzheimer's may be a progressive neurodegenerative disease that's characterized histopathologically by the presence of plaques, in the main composed of Abeta amyloid and the tangles, in the main composed of hyper phosphorylated letter. To date, there's no treatment which will reverse, and everyone the present medical specialty is directed to address the symptoms. Here we tend to describe the efforts dedicated to attack the plaques and, in additional detail, the method of neurofibrillary degeneration, joined to the presence of the hyper phosphorylated tubule associated macromolecule letter. we've got known the various supposed targets for medical specialty and the current information on them.

Treatment for presenile dementia is coming into a replacement and exciting part, with many new medicines starting clinical trials. several of those new therapies area unit supported our greatest current understanding of the pathological process of presenile dementia, and area unit designed to undertake to either slow or halt the progression. There are a unit many totally different theories underlying the present efforts, and these area unit in brief reviewed. Therapies directed against some facet of beta-amyloid formation, against neurofibrillary tangle formation and against the inflammatory response area unit all thought-about, as area unit the issues related to every space. it's however unclear that, if any of those approaches are prospering, however the high level of activity in every of those 3 fields provides some hope that an efficient treatment for presenile dementia is on the horizon.


  • Epidemiology of Neurodegenerative disease
  • Down Syndrome
  • Stroke treatments

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